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Article

Lys66 residue as a determinant of high mismatch extension and misinsertion rates of HIV-1 reverse transcriptase.

The FEBS journal - 1 Nov 2012

Lwatula Chisanga, Garforth Scott J, Prasad Vinayaka R

Abstract excerpt

A major factor contributing to the high mutation rate of HIV-1 reverse transcriptase (RT) is its high propensity for misincorporation. Misincorporation requires both deoxyribonucleotide triphosphate (dNTP) misinsertion and the subsequent extension of the mismatched terminus thus formed. We hypothesized that Lys66 is a determinant of mismatch extension based on its position near the primer terminus. This...

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Share to Anti-HIV Agents
Share to DNA Mismatch Repair
Share to HIV Reverse Transcriptase

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Hydroxyl Radical

Share to Lysine

Share to Mutagenesis, Insertional

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Share to Templates, Genetic

Source

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Identifiers

PMID: 22925131
DOI: 10.1111/j.1742-4658.2012.08807.x
PMCID: PMC3472125

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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