Article

Targeting RTN4/NoGo-Receptor reduces levels of ALS protein ataxin-2

2021-12-21

Abstract excerpt

<h4>Summary</h4> Gene-based therapeutic strategies to lower ataxin-2 levels are emerging for neurodegenerative diseases amyotrophic lateral sclerosis (ALS) and spinocerebellar ataxia type 2 (SCA2). To identify additional ways of reducing ataxin-2 levels, we performed a genome-wide screen in human cells for regulators of ataxin-2 and identified RTN4R , the gene encoding the RTN4/NoGo-Receptor, as a top hit. RTN4...

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Literature Corpus work: 3bfffba4-5d51-5b24-b518-624405f56aac
DOI: 10.1101/2021.12.20.473562

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