Article
Familial abnormalities of endocannabinoid signaling in schizophrenia.
The world journal of biological psychiatry : the official journal of the World Federation of Societies of Biological Psychiatry - 1 Feb 2019
Koethe Dagmar, Pahlisch Franziska, Hellmich Martin, Rohleder Cathrin, Mueller Juliane K, Meyer-Lindenberg Andreas, Torrey E Fuller, Piomelli Daniele, Leweke F Markus
Abstract excerpt
OBJECTIVES: Epidemiological and experimental evidence suggests that the endocannabinoid system plays a pathophysiological role in schizophrenia. This is reflected by elevated cerebrospinal levels of the endocannabinoid anandamide in schizophrenia and its initial prodromal states. METHODS: We analyzed plasma concentrations of anandamide, 2-arachidonoyl-sn-glycerol, palmitoylethanolamide and oleoylethanolamide from...
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