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Flavivirus Replication Complex Assembly Revealed by DNAJC14 Functional Mapping

22 Aug 2012

Abstract excerpt

DNAJC14 is an Hsp40 family member that broadly modulates flavivirus replication. The mechanism by which DNAJC14 stoichiometrically participates in flavivirus replication complex (RC) formation is unknown; both reduced and elevated levels result in replication inhibition. Using yellow fever virus (YFV), we demonstrate that DNAJC14 redistributes and clusters with YFV nonstructural proteins via a transmembrane...

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PMID: 22915803
DOI: 10.1128/jvi.01022-12

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