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Dengue and Zika virus NS4B proteins differ in topology and in determinants of ER membrane protein complex dependency

31 Dec 2024

Abstract excerpt

Flaviviruses utilize the cellular endoplasmic reticulum (ER) for all aspects of their lifecycle. Genome replication and other viral activities take place in structures called replication organelles (ROs), which are invaginations induced in the ER membrane. Among the required elements for RO formation is the biogenesis of viral nonstructural proteins NS4A and NS4B. We have previously shown that NS4A and NS4B from...

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PMID: 39745435
DOI: 10.1128/jvi.01443-24

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