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Article

Determinants in Nonstructural Protein 4A of Dengue Virus Required for RNA Replication and Replication Organelle Biogenesis.

Journal of virology - 13 Oct 2021

Cortese Mirko, Mulder Klaas, Chatel-Chaix Laurent, Scaturro Pietro, Cerikan Berati, Plaszczyca Anna, Haselmann Uta, Bartenschlager Marie, Neufeldt Christopher J, Bartenschlager Ralf

Abstract excerpt

Dengue virus (DENV) constitutes one of the most important arboviral pathogens affecting humans. The high prevalence of DENV infections, which cause more than 20,000 deaths annually, and the lack of effective vaccines or direct-acting antiviral drugs make it a global health concern. DENV genome replication occurs in close association with the host endomembrane system, which is remodeled to form the viral...

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Identifiers

PMID: 34379504
DOI: 10.1128/JVI.01310-21
PMCID: PMC8513467

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