Article
CD200 expression in mantle cell lymphoma identifies a unique subgroup of patients with frequent IGHV mutations, absence of SOX11 expression, and an indolent clinical course.
Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc - 1 Feb 2018
Hu Zhihong, Sun Yi, Schlette Ellen J, Tang Guilin, Li Shaoying, Xu Jie, Yin C Cameron, Young Ken H, Patel Keyur Pravinchandra, Miranda Roberto N, Goswami Maitrayee, Wang Michael, Jorgensen Jeffrey L, Medeiros L Jeffrey, Wang Sa A
Abstract excerpt
CD200, a marker currently utilized in the diagnosis of B-cell lymphoma, is uniformly positive in chronic lymphocytic leukemia/chronic lymphocytic leukemia, and is usually absent in mantle cell lymphoma. Over a 6 year-period, of 668 mantle cell lymphoma assessed by flow cytometry, CD200 expression was detected in 25 patients (~4%). All 25 patients had bone marrow involvement; however, 11 (44%) patients had no...
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