Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Impact of allele-selective silencing of von Willebrand factor in mice based on a single nucleotide allelic difference in von Willebrand factor.

Thrombosis research - 1 Apr 2024

Jongejan Yvonne K, Linthorst Noa A, Schrader Echeverri Elisa, Laan Sebastiaan N J, Dirven Richard J, Dahlman James E, van Vlijmen Bart J M, Denis Cécile V, Eikenboom Jeroen C J

Abstract excerpt

INTRODUCTION: Von Willebrand factor (VWF) plays a pathophysiological role in hemostatic disorders. Partial inhibition of the VWF gene through small interfering RNA (siRNA)-mediated allele-selective silencing could be a promising therapeutic strategy. For von Willebrand disease, allele-selectively inhibiting dominant-negative VWF-alleles might ameliorate the phenotype. For thrombotic disorders, partial VWF...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Alleles
Share to Hemorrhage

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Mice, Inbred C57BL

Share to RNA, Messenger

Share to Thrombosis

Share to von Willebrand Diseases

Share to von Willebrand Factor

Source

Identifiers

PMID: 38461614
DOI: 10.1016/j.thromres.2024.03.002

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Impact of allele-selective silencing of von Willebrand factor in mice based on a single nucleotide allelic difference in von Willebrand factor.PMID 38461614Read ↗

Small interfering RNA-mediated allele-selective silencing of von Willebrand factor in vitro and in vivo.Semantic proximity Read ↗

Amelioration of a von Willebrand disease type 2B phenotype in vivo upon treatment with allele-selective siRNAsSemantic proximity Read ↗

Correction of a dominant-negative von Willebrand factor multimerization defect by small interfering RNA-mediated allele-specific inhibition of mutant von Willebrand factor.Semantic proximity Read ↗

In vivo modulation of a dominant-negative variant in mouse models of von Willebrand disease type 2A.Semantic proximity Read ↗

Ex vivo Improvement of a von Willebrand Disease Type 2A Phenotype Using an Allele-Specific Small-Interfering RNA.Semantic proximity Read ↗

Mutation and ADAMTS13-dependent modulation of disease severity in a mouse model for von Willebrand disease type 2BSemantic proximity Read ↗

Allele-selective disruption of pathogenic VWF variants in type 2 von Willebrand disease using CRISPR/Cas9.Semantic proximity Read ↗

A mouse model of severe von Willebrand disease: defects in hemostasis and thrombosis.Semantic proximity Read ↗

The common VWF single nucleotide variants c.2365A>G and c.2385T>C modify VWF biosynthesis and clearance.Semantic proximity Read ↗

Modifiers of von Willebrand factor identified by natural variation in inbred strains of mice.Semantic proximity Read ↗

The dominant-negative von Willebrand factor gene deletion p.P1127_C1948delinsR: molecular mechanism and modulationSemantic proximity Read ↗

A synonymous (c.3390C>T) or a splice-site (c.3380-2A>G) mutation causes exon 26 skipping in four patients with von Willebrand disease (2A/IIE).Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.