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Hsp90β interacts with MDM2 to suppress p53‐dependent senescence during skeletal muscle regeneration

17 Jul 2019

Abstract excerpt

Cellular senescence plays both beneficial and detrimental roles in embryonic development and tissue regeneration, while the underlying mechanism remains elusive. Recent studies disclosed the emerging roles of heat-shock proteins in regulating muscle regeneration and homeostasis. Here, we found that Hsp90β, but not Hsp90α isoform, was significantly upregulated during muscle regeneration. RNA-seq analysis disclosed...

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PMID: 31313490
DOI: 10.1111/acel.13003

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