Article
Matrix metalloproteinase-9 genetic polymorphisms and the risk for advanced pelvic organ prolapse.
Obstetrics and gynecology - 1 Sept 2012
Wu Jennifer M, Visco Anthony G, Grass Elizabeth A, Craig Damian M, Fulton Rebekah G, Haynes Carol, Weidner Alison C, Shah Svati H
Abstract excerpt
OBJECTIVE: Matrix metalloproteinase-9 (MMP9) is a protease associated with degradation of collagen and elastin. Because increased MMP9 activity in vaginal tissue has been associated with pelvic organ prolapse (POP), we sought to comprehensively estimate MMP9 genetic variants and the risk for advanced prolapse. METHODS: This is a candidate gene association study of women with stage III-IV prolapse (case group,...
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