Article
The admixture maximum likelihood test to test for association between rare variants and disease phenotypes.
BMC bioinformatics - 6 Jun 2013
Tyrer Jonathan P, Guo Qi, Easton Douglas F, Pharoah Paul D P
Abstract excerpt
BACKGROUND: The development of genotyping arrays containing hundreds of thousands of rare variants across the genome and advances in high-throughput sequencing technologies have made feasible empirical genetic association studies to search for rare disease susceptibility alleles. As single variant testing is underpowered to detect associations, the development of statistical methods to combine analysis across...
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