Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Interaction between smoking and HLA-DRB1*04 gene is associated with a high cardiovascular risk in Brazilian Amazon patients with rheumatoid arthritis.

PloS one - 1 Jan 2012

Boechat Narjara de Oliveira, Ogusku Mauricio Morish, Boechat Antonio Luiz, Sadahiro Aya

Abstract excerpt

BACKGROUND: Rheumatoid Arthritis (RA) is an autoimmune disease characterized by chronic inflammation of the joints that affects approximately 1% of the population worldwide. The HLA-DRB1 gene locus plays a major role in genetic susceptibility to RA, a condition that has been associated with a high cardiovascular morbidity and mortality in many studies. METHODOLOGY/PRINCIPAL FINDINGS: The aim of this work was to...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Arthritis, Rheumatoid
Share to Brazil

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cardiovascular Diseases

Share to Genotype

Share to HLA-DRB1 Chains

Share to Logistic Models

Share to Smoking

Source

Open in PubMed Open full text

Identifiers

PMID: 22912672
DOI: 10.1371/journal.pone.0041588
PMCID: PMC3418250

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Interaction between smoking and HLA-DRB1*04 gene is associated with a high cardiovascular risk in Brazilian Amazon patients with rheumatoid arthritis.PMID 22912672Read ↗

The Genetic Variants of HLA-DRB1 Alleles and the Chance of Developing Rheumatoid Arthritis: Systematic Review and meta-analysisSemantic proximity Read ↗

HLA class II alleles influence rheumatoid arthritis susceptibility and autoantibody status in South Indian Tamil population.Semantic proximity Read ↗

The Impact of Cigarette Smoking on Risk of Rheumatoid Arthritis: A Narrative Review.Semantic proximity Read ↗

Associative role of HLA-DRB1 SNP genotypes as risk factors for susceptibility and severity of rheumatoid arthritis: A North-east Indian population-based study.Semantic proximity Read ↗

Current Understanding of an Emerging Role of HLA-DRB1 Gene in Rheumatoid Arthritis-From Research to Clinical Practice.Semantic proximity Read ↗

Epidemiology and genetics of rheumatoid arthritis.Semantic proximity Read ↗

HLA-DRB1 and persistent chronic inflammation contribute to cardiovascular events and cardiovascular mortality in patients with rheumatoid arthritis.Semantic proximity Read ↗

Association study of human leukocyte antigen-DRB1 alleles with rheumatoid arthritis in Algerian patients.Semantic proximity Read ↗

Interaction of HLA-DRB1*09:01 and *04:05 with smoking suggests distinctive mechanisms of rheumatoid arthritis susceptibility beyond the shared epitope.Semantic proximity Read ↗

Novel risk factors for cardiovascular disease in rheumatoid arthritis.Semantic proximity Read ↗

Alleles of HLA-DRB1*04 Associated with Pulmonary Tuberculosis in Amazon Brazilian Population.Semantic proximity Read ↗

Genetic landscape of interactive effects of HLA-DRB1 alleles on susceptibility to ACPA(+) rheumatoid arthritis and ACPA levels in Japanese population.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.