Article
Markers of endogenous desaturase activity and risk of coronary heart disease in the CAREMA cohort study.
PloS one - 1 Jan 2012
Lu Yingchang, Vaarhorst Anika, Merry Audrey H H, Dollé Martijn E T, Hovenier Robert, Imholz Sandra, Schouten Leo J, Heijmans Bastiaan T, Müller Michael, Slagboom P Eline, van den Brandt Piet A, Gorgels Anton P M, Boer Jolanda M A, Feskens Edith J M
Abstract excerpt
BACKGROUND: Intakes of n-3 polyunsaturated fatty acids (PUFAs), especially EPA (C20:5n-3) and DHA (C22:6n-3), are known to prevent fatal coronary heart disease (CHD). The effects of n-6 PUFAs including arachidonic acid (C20:4n-6), however, remain unclear. δ-5 and δ-6 desaturases are rate-limiting enzymes for synthesizing long-chain n-3 and n-6 PUFAs. C20:4n-6 to C20:3n-6 and C18:3n-6 to C18:2n-6 ratios are...
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