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Article

Clinical translation of cell-based pharmacogenomic discovery.

Clinical pharmacology and therapeutics - 1 Oct 2012

Cox N J, Gamazon E R, Wheeler H E, Dolan M E

Abstract excerpt

The use of cell-based models has emerged as a promising means to discover and validate pharmacologic phenotype-genotype relationships. The availability of large-scale genome studies in both human and model systems is now allowing us an unprecedented opportunity to understand how well cell-based models identify clinically relevant genetic variants associated with drug response and toxicity. Here we review these...

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Identifiers

PMID: 22910437
DOI: 10.1038/clpt.2012.115
PMCID: PMC3664667

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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