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Tumor-induced double positive T cells display distinct lineage commitment mechanisms and functions

23 May 2022

Abstract excerpt

Transcription factors ThPOK and Runx3 regulate the differentiation of "helper" CD4+ and "cytotoxic" CD8+ T cell lineages respectively, inducing single positive (SP) T cells that enter the periphery with the expression of either the CD4 or CD8 co-receptor. Despite the expectation that these cell fates are mutually exclusive and that mature CD4+CD8+ double positive (DP) T cells are present in healthy individuals...

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PMID: 35604411
DOI: 10.1084/jem.20212169

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