Common variants in the GDF5-UQCC region are associated with variation in human height.

doi:10.1038/ng.74

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Community

Back to search

Article

Common variants in the GDF5-UQCC region are associated with variation in human height.

Nature genetics - 1 Feb 2008

Sanna Serena, Jackson Anne U, Nagaraja Ramaiah, Willer Cristen J, Chen Wei-Min, Bonnycastle Lori L, Shen Haiqing, Timpson Nicholas, Lettre Guillaume, Usala Gianluca, Chines Peter S, Stringham Heather M, Scott Laura J, Dei Mariano, Lai Sandra, Albai Giuseppe, Crisponi Laura, Naitza Silvia, Doheny Kimberly F, Pugh Elizabeth W, Ben-Shlomo Yoav, Ebrahim Shah, Lawlor Debbie A, Bergman Richard N, Watanabe Richard M, Uda Manuela, Tuomilehto Jaakko, Coresh Josef, Hirschhorn Joel N, Shuldiner Alan R, Schlessinger David, Collins Francis S, Davey Smith George, Boerwinkle Eric, Cao Antonio, Boehnke Michael, Abecasis Gonçalo R, Mohlke Karen L

Abstract excerpt

Identifying genetic variants that influence human height will advance our understanding of skeletal growth and development. Several rare genetic variants have been convincingly and reproducibly associated with height in mendelian syndromes, and common variants in the transcription factor gene HMGA2 are associated with variation in height in the general population. Here we report genome-wide association analyses,...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to 5' Untranslated Regions

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Body Height

Share to Bone Morphogenetic Proteins

Share to Chromosomes, Human, Pair 20

Share to Confounding Factors, Epidemiologic

Share to Growth Differentiation Factor 5

Share to HMGA2 Protein

Share to Osteoarthritis

Source

Open in PubMed Open full text

Identifiers

PMID: 18193045
DOI: 10.1038/ng.74
PMCID: PMC2914680

Genes

GDF5
HMGA2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Common variants in the GDF5-UQCC region are associated with variation in human height.PMID 18193045Read ↗

A common variant of HMGA2 is associated with adult and childhood height in the general population.Semantic proximity Read ↗

Defining the role of common variation in the genomic and biological architecture of adult human height.Semantic proximity Read ↗

Reaching new heights: insights into the genetics of human stature.Semantic proximity Read ↗

Rare protein-coding variation and the genetic architecture of height in >1.4 million individualsSemantic proximity Read ↗

Meta-analysis of genome-wide scans for human adult stature identifies novel Loci and associations with measures of skeletal frame size.Semantic proximity Read ↗

Height matters-from monogenic disorders to normal variation.Semantic proximity Read ↗

The role of height-associated loci identified in genome wide association studies in the determination of pediatric stature.Semantic proximity Read ↗

Insights and Implications of Genome-Wide Association Studies of HeightSemantic proximity Read ↗

Your height affects your health: genetic determinants and health-related outcomes in Taiwan.Semantic proximity Read ↗

Genetic variation in the GDF5 region is associated with osteoarthritis, height, hip axis length and fracture risk: the Rotterdam study.Semantic proximity Read ↗

Whole-genome sequencing in 333,100 individuals reveals rare non-coding single variant and aggregate associations with height.Semantic proximity Read ↗

Hundreds of variants clustered in genomic loci and biological pathways affect human height.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.