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A new gut pathogenic bacteria and its metabolites promote colorectal cancer development and act as non-invasive early diagnostic biomarkers

5 Sept 2025

Abstract excerpt

Gut microbiota dysbiosis is strongly linked to colorectal cancer (CRC), but reliable early diagnostic markers remain elusive. This study investigates the role of a novel Shigella flexneri strain in CRC pathogenesis. Metabolomic analysis of CRC patient feces identified elevated agmatine levels. A unique agmatine-producing strain (S. flexneri C.11) was isolated and validated in cell models and pseudo-sterile mice....

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PMID: 40911847
DOI: 10.1080/19490976.2025.2555446

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

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