Article
Exposure to ambient particulate matter induces a NASH-like phenotype and impairs hepatic glucose metabolism in an animal model.
Journal of hepatology - 1 Jan 2013
Zheng Ze, Xu Xiaohua, Zhang Xuebao, Wang Aixia, Zhang Chunbin, Hüttemann Maik, Grossman Lawrence I, Chen Lung Chi, Rajagopalan Sanjay, Sun Qinghua, Zhang Kezhong
Abstract excerpt
BACKGROUND & AIMS: Air pollution is a global challenge to public health. Epidemiological studies have linked exposure to ambient particulate matter with aerodynamic diameters<2.5 μm (PM(2.5)) to the development of metabolic diseases. In this study, we investigated the effect of PM(2.5) exposure on liver pathogenesis and the mechanism by which ambient PM(2.5) modulates hepatic pathways and glucose homeostasis....
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