Article
Inactivation of TNF/LT locus alters mouse metabolic response to concentrated ambient PM2.5.
Toxicology - 1 Sept 2017
Hu Ziying, Chen Minjie, Zhou Huifen, Tharakan Anui, Wang Xiaoke, Qiu Lianglin, Liang Shuai, Qin Xiaobo, Zhang Yuhao, Wang Wanjun, Xu Yanyi, Ying Zhekang
Abstract excerpt
BACKGROUND: Exposure to ambient fine particulate matter (PM2.5) is associated with increased cardiometabolic morbidity and mortality. This is widely believed to be attributable to PM2.5 exposure-induced pulmonary and subsequent systemic inflammation. Tumor necrosis factor alpha (TNFα), lymphotoxin α (LTα), and lymphotoxin β (LTβ) are three homologous pro-inflammatory cytokines, each with both unique and redundant...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.