Ambient fine particulate matter components and liver fat and stiffness in youth: metabolic vulnerability in PNPLA3 risk carriers.

doi:10.1016/j.envint.2026.110438

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Article

Ambient fine particulate matter components and liver fat and stiffness in youth: metabolic vulnerability in PNPLA3 risk carriers.

Environment international - 1 Sept 2026

Li Haonan, Schenker Rachel B, Marquess Katherine M, Paudel Devendra, Ramirez Cuauhtemoc B, Lurmann Fredrick, Ren Mengyuan, Jang Cholsoon, Allayee Hooman, Liao Jiawen, Chen Zhanghua, Goran Michael I, Alderete Tanya L

Abstract excerpt

BACKGROUND & AIMS: Exposure to fine particulate matter (PM2.5) is linked to metabolic dysfunction-associated steatotic liver disease (MASLD), yet responsible chemical constituents and the biological basis of susceptibility remain unclear, limiting source-targeted regulation and precision prevention in vulnerable populations. We examined PM2.5 components - liver outcomes associations in youth, assessed...

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Topics

Humans
Acyltransferases
Phospholipases A2, Calcium-Independent
Lipase
Particulate Matter

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Membrane Proteins

Liver

Male

Female

Adolescent

Fatty Liver

Genotype

Los Angeles

Air Pollutants

Environmental Exposure

Source

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Identifiers

PMID: 42561592
DOI: 10.1016/j.envint.2026.110438
PMCID: PMC13680008

Genes

PNPLA3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 24 Oct 2026.

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