PM2.5 promotes the phenotypic transition of vascular smooth muscle cells in atherosclerosis by activating pro-ferroptotic signaling via DRP1/PINK1/Parkin-dependent mitophagy.

Abstract excerpt

Fine particulate matter (PM2.5), as a widespread environmental pollutant, is closely associated with cardiovascular diseases. The adverse effects of PM2.5 on the cardiovascular system and the molecular mechanisms driving PM2.5-aggravated atherosclerosis remain incompletely understood. In this study, in vivo and in vitro PM2.5 exposure models were established to explore the relevant pathogenic mechanisms. Male...

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