Article
A restricted level of PQBP1 is needed for the best longevity of Drosophila.
Neurobiology of aging - 1 Jan 2013
Tamura Takuya, Sone Masaki, Nakamura Yoko, Shimamura Teppei, Imoto Seiya, Miyano Satoru, Okazawa Hitoshi
Abstract excerpt
A number of neurological diseases are caused by mutations of RNA metabolism-related genes. A complicating issue is that whether under- or overfunction of such genes is responsible for the phenotype. Polyglutamine tract binding protein-1, a causative gene for X-linked mental retardation, is also involved in RNA metabolism, and both mutation and duplication of the gene were reported in human patients. In this...
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