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Article

A Novel Class of FKBP12 Ligands Rescues Premature Aging Phenotypes Associated with Myotonic Dystrophy Type 1.

Cells - 22 Nov 2024

García-Puga Mikel, Gerenu Gorka, Bargiela Ariadna, Espinosa-Espinosa Jorge, Mosqueira-Martín Laura, Sagartzazu-Aizpurua Maialen, Aizpurua Jesús M, Vallejo-Illarramendi Ainara, Artero Rubén, López de Munain Adolfo, Matheu Ander

Abstract excerpt

Background: Myotonic dystrophy type 1 (DM1) is an autosomal dominant disorder clinically characterized by progressive muscular weakness and multisystem degeneration, which correlates with the size of CTG expansion and MBLN decrease. These changes induce a calcium and redox homeostasis imbalance in several models that recapitulate the features of premature tissue aging. In this study, we characterized the impact...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 39682688
DOI: 10.3390/cells13231939
PMCID: PMC11639790

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