Catechol-O-methyltransferase (COMT) genotype biases neural correlates of empathy and perceived personal distress in schizophrenia.

doi:10.1016/j.comppsych.2012.06.008

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Article

Catechol-O-methyltransferase (COMT) genotype biases neural correlates of empathy and perceived personal distress in schizophrenia.

Comprehensive psychiatry - 1 Feb 2013

Poletti Sara, Radaelli Daniele, Cavallaro Roberto, Bosia Marta, Lorenzi Cristina, Pirovano Adele, Smeraldi Enrico, Benedetti Francesco

Abstract excerpt

BACKGROUND: The catechol-O-methyltransferase (COMT) Val(108/158)Met polymorphism (rs4680) influences enzyme activity with valine (Val) allele associated with higher enzymatic activity. Several studies suggest that factors influencing dopaminergic transmission could control response to stressful situations. Empathy is an essential element of human behavior, requires the ability to adopt another person's...

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PMID: 22901597
DOI: 10.1016/j.comppsych.2012.06.008

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COMT

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

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