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Article

The Protective Effect of Minocycline in a Paraquat-Induced Parkinson's Disease Model inDrosophilais Modified in Altered Genetic Backgrounds

1 Jan 2012

Abstract excerpt

Epidemiological studies link the herbicide paraquat to increased incidence of Parkinson's disease (PD). We previously reported that Drosophila exposed to paraquat recapitulate PD symptoms, including region-specific degeneration of dopaminergic neurons. Minocycline, a tetracycline derivative, exerts ameliorative effects in neurodegenerative disease models, including Drosophila. We investigated whether our...

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PMID: 22900232
DOI: 10.1155/2012/938528

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