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Article

Toxicogenetics--cytochrome P450 microarray analysis in forensic cases focusing on morphine/codeine and diazepam.

International journal of legal medicine - 1 Mar 2013

Andresen H, Augustin C, Streichert T

Abstract excerpt

Genetic polymorphisms in cytochrome P 450 (CYP) enzymes could lead to a phenotype with altered enzyme activity. In pharmacotherapy, genotype-based dose recommendations achieved great importance for several drugs. In our pilot study, we ask if these genetic tests should be applied to forensic problems as a matter of routine. Starting from 2004 through 2008, we screened routine cases for samples where the relation...

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PMID: 22899355
DOI: 10.1007/s00414-012-0759-6

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