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Article

The Ubiquitin-Proteasome System as a Prospective Molecular Target for Cancer Treatment and Prevention

16 Jul 2010

Abstract excerpt

Proteasomes are large multicatalytic proteinase complexes located in the cytosol and the nucleus of eukaryotic cells. The ubiquitin-proteasome system is responsible for the degradation of most intracellular proteins and therefore plays an essential regulatory role in critical cellular processes including cell cycle progression, proliferation, differentiation, angiogenesis and apoptosis. Besides involving in...

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PMID: 20491623
DOI: 10.2174/138920310791824057

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