Article
Apoptosis meets proteasome, an invaluable therapeutic target of anticancer drugs.
The Italian journal of biochemistry - 1 Jun 2003
Giuliano Michela, D'Anneo Antonella, De Blasio Anna, Vento Renza, Tesoriere Giovanni
Abstract excerpt
This report reviews the current status of extensive efforts directed towards the interpretation of crosstalk between apoptosis and proteasome to understanding the molecular mechanism of anticancer agents targeting proteasome, with particular focus on MG132 and PS-341. The discovery that all cancer cells have retained the apoptotic death program has offered to the researchers new biochemical targets to design...
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