Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The association of the R563Q genotype of the ENaC with phenotypic variation in Southern Africa.

American journal of hypertension - 1 Dec 2012

Jones Erika S W, Owen E Patricia, Rayner Brian L

Abstract excerpt

BACKGROUND: The epithelial sodium channel (ENaC) may be a common underlying pathway for the development of primary hypertension. In South Africa, the R563Q variant of the ENaC is associated with low-renin-low-aldosterone hypertension and preeclampsia in black Africans and mixed-ancestry peoples. The purpose of this study was to investigate the prevalence of the R563Q variant in the multiethnic populations of...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Amiloride
Share to Antihypertensive Agents
Share to Black People

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Blood Pressure

Share to Chi-Square Distribution

Share to Epithelial Sodium Channels

Share to Hypertension

Share to South Africa

Source

Identifiers

PMID: 22895453
DOI: 10.1038/ajh.2012.125

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The association of the R563Q genotype of the ENaC with phenotypic variation in Southern Africa.PMID 22895453Read ↗

The R563Q mutation of the epithelial sodium channel beta-subunit is associated with hypertension.Semantic proximity Read ↗

Association of pre-eclampsia with the R563Q mutation of the beta-subunit of the epithelial sodium channel.Semantic proximity Read ↗

T594M variant of the epithelial sodium channel beta-subunit gene and hypertension in individuals of African ancestry in South Africa.Semantic proximity Read ↗

Genetic variation in the epithelial sodium channel: a risk factor for hypertension in people of African origin.Semantic proximity Read ↗

Pharmacogenomics of Hypertension in Africa: Paving the Way for a Pharmacogenetic‐Based Approach for the Treatment of Hypertension in AfricansSemantic proximity Read ↗

A new mutation, R563Q, of the beta subunit of the epithelial sodium channel associated with low-renin, low-aldosterone hypertension.Semantic proximity Read ↗

Single Nucleotide Polymorphisms in Amlodipine-Associated Genes and Their Correlation with Blood Pressure Control among South African Adults with Hypertension.Semantic proximity Read ↗

Hypertension in African Populations: Review and Computational Insights.Semantic proximity Read ↗

Computational analysis of candidate disease genes and variants for salt-sensitive hypertension in indigenous Southern Africans.Semantic proximity Read ↗

High Frequency of Variants of Candidate Genes in Black Africans with Low Renin-Resistant Hypertension.Semantic proximity Read ↗

Cross-sectional study of the association of 5 single nucleotide polymorphisms with enalapril treatment response among South African adults with hypertension.Semantic proximity Read ↗

Genetic Variation in Hydrochlorothiazide Response-Related Genes Among Hypertensive Individuals in Soweto, South Africa.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.