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Article

High Frequency of Variants of Candidate Genes in Black Africans with Low Renin-Resistant Hypertension.

American journal of hypertension - 1 May 2017

Jones Erika S, Spence J D, Mcintyre Adam D, Nondi Justus, Gogo Kennedy, Akintunde Adeseye, Hackam Daniel G, Rayner Brian L

Abstract excerpt

OBJECTIVES: Black subjects tend to retain salt and water, be more sensitive to aldosterone, and have suppression of plasma renin activity. Variants of the renal sodium channel (ENaC, SCNN1B) account for approximately 6% of resistant hypertension (RHT) in Blacks; other candidate genes may be important. METHODS: Six candidate genes associated with low renin-resistant hypertension were sequenced in Black Africans...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 28052878
DOI: 10.1093/ajh/hpw167

Genes

GRK4
NPPA
UMOD

Variants

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