Article
Presence of an enlarged pool of MOPC-315-specific cytotoxic T lymphocyte precursors in the thymuses of mice that eradicated a large MOPC-315 tumor as a consequence of low-dose melphalan therapy.
Cancer immunology, immunotherapy : CII - 1 Jan 1990
Bartik M M, Ahn M C, Baumgartel B A, Hendricks R L, Mokyr M B
Abstract excerpt
We have previously shown that, as a consequence of low-dose melphalan (L-phenylalanine mustard) treatment, thymocytes from mice bearing a large, day-10 MOPC-315 tumor, but not thymocytes from normal mice, acquire the ability to generate an enhanced level of antitumor cytotoxicity upon in vitro stimulation with MOPC-315 tumor cells plus low concentrations (9.0-90 IU/ml) of exogenous interleukin-2 (IL-2). Here we...
Topics
- Animals
- Cell Survival
- Dose-Response Relationship, Drug
- Female
- Interleukin-2
- Lymphocyte Activation
- Melphalan
- Mice
- Mice, Inbred BALB C
- Neoplasm Transplantation