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Article

Insulin-like growth factor 1 mediates negative feedback to somatotroph GH expression via POU1F1/CREB binding protein interactions.

Molecular and cellular biology - 1 Nov 2012

Romero Christopher J, Pine-Twaddell Elyse, Sima Daniela I, Miller Ryan S, He Ling, Wondisford Fredric, Radovick Sally

Abstract excerpt

Circulating insulin-like growth factor 1 (IGF-1) has been shown to act as a negative feedback regulator of growth hormone (GH) gene expression; however, the mechanism of this negative feedback is poorly understood. Activation and regulation of GH gene expression require the binding of the transcr...

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Identifiers

PMID: 22890843
DOI: 10.1128/MCB.00171-12
PMCID: PMC3486141

Genes

GHRH

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-22890843-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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