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Article

C/EBPβ mediates growth hormone-regulated expression of multiple target genes.

Molecular endocrinology (Baltimore, Md.) - 1 Apr 2011

Cui Tracy X, Lin Grace, LaPensee Christopher R, Calinescu Anda-Alexandra, Rathore Maanjot, Streeter Cale, Piwien-Pilipuk Graciela, Lanning Nathan, Jin Hui, Carter-Su Christin, Qin Zhaohui S, Schwartz Jessica

Abstract excerpt

Regulation of c-Fos transcription by GH is mediated by CCAAT/enhancer binding protein β (C/EBPβ). This study examines the role of C/EBPβ in mediating GH activation of other early response genes, including Cyr61, Btg2, Socs3, Zfp36, and Socs1. C/EBPβ depletion using short hairpin RNA impaired responsiveness of these genes to GH, as seen for c-Fos. Rescue with wild-type C/EBPβ led to GH-dependent recruitment of the...

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Identifiers

PMID: 21292824
DOI: 10.1210/me.2010-0232
PMCID: PMC3063086

Genes

EBP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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