Article
Lack of association between the CC genotype of the rs7903146 polymorphism in the TCF7L2 gene and rheumatoid arthritis.
Revista brasileira de reumatologia - 1 Aug 2012
Mota Licia Maria Henrique da, Rabelo Francieli de Souza, Lima Francisco Aires Corrêa, Lima Rodrigo Aires Corrêa, Carvalho Jozélio Freire de, Barra Gustavo Barcelos, Amato Angélica Amorim
Abstract excerpt
INTRODUCTION: TCF7L2 is a transcription factor involved in Wnt/beta-catenin signaling and which has a variant known to be consistently associated with type 2 diabetes risk and some studies have also indicated its association with risk of certain types of cancer. OBJECTIVE: Since this pathway may be involved in the pathophysiology of other chronic inflammatory diseases such as rheumatoid arthritis, we aimed to...
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