Article
Association of the rs7903146 single nucleotide polymorphism at the Transcription Factor 7-like 2 (TCF7L2) locus with type 2 diabetes in Brazilian subjects.
Arquivos brasileiros de endocrinologia e metabologia - 1 Nov 2012
Barra Gustavo Barcelos, Dutra Ludmila Alves Sanches, Watanabe Sílvia Conde, Costa Patrícia Godoy Garcia, Cruz Patrícia Sales Marques da, Azevedo Monalisa Ferreira, Amato Angélica Amorim
Abstract excerpt
OBJECTIVE: To investigate the association of the T allele of the single nucleotide polymorphism (SNP) rs7903146 of TCF7L2 with the occurrence of T2D in a sample of subjects followed up at the Brasilia University Hospital. SUBJECTS AND METHODS: The SNP rs7903146 of TCF7L2 was genotyped by allele-specific PCR in 113 patients with known T2D and in 139 non-diabetic controls in Brasilia, Brazil. RESULTS: We found that...
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