Article
SLC22A4 polymorphisms implicated in rheumatoid arthritis and Crohn's disease are not associated with rheumatoid arthritis in a Canadian Caucasian population.
Arthritis and rheumatism - 1 Feb 2005
Newman Bill, Wintle Richard F, van Oene Mark, Yazdanpanah Mehrdad, Owen Julie, Johnson Ben, Gu Xiangjun, Amos Christopher I, Keystone Edward, Rubin Laurence A, Siminovitch Katherine A
Abstract excerpt
OBJECTIVE: Single-nucleotide polymorphisms (SNPs) in the SLC22A4 gene encoding the organic cation transporter OCTN1 have been associated with rheumatoid arthritis (RA) in the Japanese population and with Crohn's disease in a Canadian cohort. The RA-associated and Crohn's disease-associated SNPs include, respectively, an intronic variant (slc2F2) and an exonic variant (1672T). We used a case-control approach to...
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