Article
Up-regulation of Cbl-b is associated with LSECtin-mediated inhibition of different CD4+ T-cell subsets.
Immunobiology - 1 Apr 2013
Zhao Dianyuan, Zhang Mengyao, Wang Min, Liu Biao, Wang Xiaowen, Yang Juntao, He Fuchu, Tang Li
Abstract excerpt
Recently, LSECtin was identified as a co-inhibitory molecule involved in the control of T cell-mediated acute liver injury. However, it is not known whether LSECtin also suppresses the function of different CD4(+) T-cell subsets. In this study, we demonstrate that LSECtin-mediated signaling potently inhibits the proliferation and IL-2 production of total, naive and pre-activated CD4(+) T cells. However, exogenous...
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