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Article

Genetic variation in dopaminergic activity is associated with the risk for psychiatric side effects of levetiracetam.

Epilepsia - 1 Jan 2013

Helmstaedter Christoph, Mihov Yoan, Toliat Mohammad R, Thiele Holger, Nuernberg Peter, Schoch Susanne, Surges Rainer, Elger Christian E, Kunz Wolfram S, Hurlemann René

Abstract excerpt

PURPOSE: Levetiracetam (LEV) is a highly effective antiepileptic agent. A clinically relevant psychiatric complication of LEV treatment, however, is the provocation of irritability and aggression. Recent behavioral research indicates that personality traits may predispose to these side effects. To assess the genetic basis of the adverse psychotropic profile of LEV, a candidate gene-based two-stage association...

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Source

Identifiers

PMID: 22881836
DOI: 10.1111/j.1528-1167.2012.03603.x

Genes

COMT
DBH

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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