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Article

Enhanced ADCC activity of affinity maturated and Fc-engineered mini-antibodies directed against the AML stem cell antigen CD96.

PloS one - 1 Jan 2012

Mohseni Nodehi Sahar, Repp Roland, Kellner Christian, Bräutigam Joachim, Staudinger Matthias, Schub Natalie, Peipp Matthias, Gramatzki Martin, Humpe Andreas

Abstract excerpt

CD96, a cell surface antigen recently described to be preferentially expressed on acute myeloid leukemia (AML) leukemic stem cells (LSC) may represent an interesting target structure for the development of antibody-based therapeutic approaches. The v-regions from the CD96-specific hybridoma TH-11...

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Share to Antibody Affinity
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Antigens, Neoplasm

Share to Dose-Response Relationship, Immunologic

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Source

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Identifiers

PMID: 22879978
DOI: 10.1371/journal.pone.0042426
PMCID: PMC3411760

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-22879978-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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