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Article

A novel mutation in β integrin reveals an integrin-mediated interaction between the extracellular matrix and cki-1/p27KIP1.

PloS one - 1 Jan 2012

Kihira Shingo, Yu Eun Jeong, Cunningham Jessica, Cram Erin J, Lee Myeongwoo

Abstract excerpt

The cell-extracellular matrix (ECM) interaction plays an essential role in maintaining tissue shapes and regulates cell behaviors such as cell adhesion, differentiation and proliferation. The mechanism by which the ECM influences the cell cycle in vivo is poorly understood. Here we demonstrate that the β integrin PAT-3 regulates the localization and expression of CKI-1, a C. elegans homologue of the cyclin...

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Share to Caenorhabditis elegans Proteins
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 22879977
DOI: 10.1371/journal.pone.0042425
PMCID: PMC3412830

Genes

CUL1
ILK
SKP2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

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