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Article

The NOD2insC polymorphism is associated with worse outcome following ileal pouch-anal anastomosis for ulcerative colitis.

Gut - 1 Oct 2013

Tyler Andrea D, Milgrom Raquel, Stempak Joanne M, Xu Wei, Brumell John Hunter, Muise Aleixo M, Sehgal Rishabh, Cohen Zane, Koltun Walter, Shen Bo, Silverberg Mark S

Abstract excerpt

BACKGROUND: Inflammatory complications after ileal pouch-anal anastomosis (IPAA) for ulcerative colitis (UC) are common. OBJECTIVE: To investigate whether genetic factors are associated with adverse pouch outcomes such as chronic pouchitis (CP) and a Crohn's disease-like (CDL) phenotype. DESIGN: 866 patients were recruited from three centres in North America: Mount Sinai Hospital (Toronto, Ontario, Canada), the...

Read the complete abstract on PubMed

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 22879519
DOI: 10.1136/gutjnl-2011-301957

Genes

DAGLB
NCF4
NOX3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

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The NOD2insC polymorphism is associated with worse outcome following ileal pouch-anal anastomosis for ulcerative colitis.PMID 22879519Read ↗

NOD2/CARD15 mutations correlate with severe pouchitis after ileal pouch-anal anastomosis.Semantic proximity Read ↗

The NOD2 single nucleotide polymorphisms rs2066843 and rs2076756 are novel and common Crohn's disease susceptibility gene variants.Semantic proximity Read ↗

NOD2 gene variant is a risk factor for postoperative complications in patients with Crohn's disease: A genetic association study.Semantic proximity Read ↗

Crohn's disease-related single nucleotide polymorphisms are associated with ileal pouch afferent limb stenosis.Semantic proximity Read ↗

Genetic risk profiling and gene signature modeling to predict risk of complications after IPAA.Semantic proximity Read ↗

The NOD2 Single Nucleotide Polymorphism rs72796353 (IVS4+10 A>C) Is a Predictor for Perianal Fistulas in Patients with Crohn's Disease in the Absence of Other NOD2 Mutations.Semantic proximity Read ↗

The prognostic power of the NOD2 genotype for complicated Crohn's disease: a meta-analysis.Semantic proximity Read ↗

Development of a uniform, very aggressive disease phenotype in all homozygous carriers of the NOD2 mutation p.Leu1007fsX1008 with Crohn's disease and active smoking status resulting in ileal stenosis requiring surgery.Semantic proximity Read ↗

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NOD2 Genetic Variants Predispose One of Two Familial Adenomatous Polyposis Siblings to Pouchitis Through Microbiome Dysbiosis.Semantic proximity Read ↗

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