Article
HIV-1 neutralizing antibodies display dual recognition of the primary and coreceptor binding sites and preferential binding to fully cleaved envelope glycoproteins.
Journal of virology - 1 Oct 2012
Li Yuxing, O'Dell Sijy, Wilson Richard, Wu Xueling, Schmidt Stephen D, Hogerkorp Carl-Magnus, Louder Mark K, Longo Nancy S, Poulsen Christian, Guenaga Javier, Chakrabarti Bimal K, Doria-Rose Nicole, Roederer Mario, Connors Mark, Mascola John R, Wyatt Richard T
Abstract excerpt
The gp120 CD4 binding site (CD4bs) and coreceptor binding site (CoRbs) are two functionally conserved elements of the HIV-1 envelope glycoproteins (Env). We previously defined the presence of CD4bs-neutralizing antibodies in the serum of an HIV-1-infected individual and subsequently isolated the CD4bs-specific monoclonal antibodies (MAbs) VRC01 and VRC03 from the memory B cell population. Since this donor's serum...
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