Article
One SNP in the 3'-UTR of HMGB1 gene affects the binding of target bta-miR-223 and is involved in mastitis in dairy cattle.
Immunogenetics - 1 Nov 2012
Li Liming, Huang Jinming, Zhang Xiaojian, Ju Zhihua, Qi Chao, Zhang Yan, Li Qiuling, Wang Changfa, Miao Weiran, Zhong Jifeng, Hou Minghai, Hang Suqin
Abstract excerpt
High-mobility group box protein 1 (HMGB1) gene has a universal sentinel function for nucleic acid-mediated innate immune responses and acts as a pathogenic mediator in the inflammatory disease. In an effort to identify the functional single-nucleotide polymorphism (SNP) in the 3'-untranslated region (UTR) of the bovine HMGB1 gene that affects the binding to its target microRNA, first, the expression of HMGB1 mRNA...
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