Using gene-network landscape to dissect genotype effects of TCF7L2 genetic variant on diabetes and cardiovascular risk.

doi:10.1152/physiolgenomics.00030.2012

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Using gene-network landscape to dissect genotype effects of TCF7L2 genetic variant on diabetes and cardiovascular risk.

Physiological genomics - 2 Oct 2012

Vaquero Andre R, Ferreira Noely E, Omae Samantha V, Rodrigues Mariliza V, Teixeira Samantha K, Krieger Jose E, Pereira Alexandre C

Abstract excerpt

The single nucleotide polymorphism (SNP) within the TCF7L2 gene, rs7903146, is, to date, the most significant genetic marker associated with Type 2 diabetes mellitus (T2DM) risk. Nonetheless, its functional role in disease pathology is poorly understood. The aim of the present study was to investigate, in vascular smooth muscle cells from 92 patients undergoing aortocoronary bypass surgery, the contribution of...

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PMID: 22872755
DOI: 10.1152/physiolgenomics.00030.2012

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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