Single nucleotide polymorphisms of TCF7L2 are linked to diabetic coronary atherosclerosis.

doi:10.1371/journal.pone.0017978

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Article

Single nucleotide polymorphisms of TCF7L2 are linked to diabetic coronary atherosclerosis.

PloS one - 15 Mar 2011

Muendlein Axel, Saely Christoph H, Geller-Rhomberg Simone, Sonderegger Gudrun, Rein Philipp, Winder Thomas, Beer Stefan, Vonbank Alexander, Drexel Heinz

Abstract excerpt

BACKGROUND: Coronary artery disease (CAD) shares common risk factors with type 2 diabetes (T2DM). Variations in the transcription factor 7-like 2 (TCF7L2) gene, particularly rs7903146, increase T2DM risk. Potential links between genetic variants of the TCF7L2 locus and coronary atherosclerosis are uncertain. We therefore investigated the association between TCF7L2 polymorphisms and angiographically determined CAD...

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PMID: 21423583
DOI: 10.1371/journal.pone.0017978
PMCID: PMC3058059

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