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Article

Structural and biochemical characterization of a trapped coenzyme A adduct of Caenorhabditis elegans glucosamine-6-phosphate N-acetyltransferase 1.

Acta crystallographica. Section D, Biological crystallography - 1 Aug 2012

Dorfmueller Helge C, Fang Wenxia, Rao Francesco V, Blair David E, Attrill Helen, van Aalten Daan M F

Abstract excerpt

Glucosamine-6-phosphate N-acetyltransferase 1 (GNA1) produces GlcNAc-6-phosphate from GlcN-6-phosphate and acetyl coenzyme A. Early mercury-labelling experiments implicated a conserved cysteine in the reaction mechanism, whereas recent structural data appear to support a mechanism in which this cysteine plays no role. Here, two crystal structures of Caenorhabditis elegans GNA1 are reported, revealing an unusual...

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Identifiers

PMID: 22868768
DOI: 10.1107/S0907444912019592
PMCID: PMC3413214

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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