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Article

A dilated cardiomyopathy troponin C mutation lowers contractile force by reducing strong myosin-actin binding.

The Journal of biological chemistry - 4 Jun 2010

Dweck David, Reynaldo Daniel P, Pinto Jose R, Potter James D

Abstract excerpt

In this study we explore the mechanisms by which a double mutation (E59D/D75Y) in cardiac troponin C (CTnC) associated with dilated cardiomyopathy reduces the Ca(2+)-activated maximal tension of cardiac muscle. Studying the single mutants (i.e. E59D or D75Y) indicates that D75Y, but not E59D, causes a reduction in the calcium affinity of CTnC in troponin complex, regulated thin filaments (RTF), and the Ca(2+)...

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Identifiers

PMID: 20371872
DOI: 10.1074/jbc.M109.064105
PMCID: PMC2878500

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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