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Article

Structural basis for the selectivity of 3rd generation EGFR inhibitors: a molecular dynamics study.

Journal of biomolecular structure & dynamics - 1 Jan 2000

Gad Mazen M, Abdelwaly Ahmad, Helal Mohamed A

Abstract excerpt

Activating mutations in the EGFR kinase domain are known to be a common cause of Non-Small Cell Lung Cancer (NSCLC) and are thus targeted for treatment. First generation Tyrosine Kinase Inhibitors (TKIs) were used to treat NSCLC patients with the known activating mutations L858R and exon 19 deletion but were resisted by a second mutation T790M in the active site of the kinase domain. Second generation members of...

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PMID: 35903965
DOI: 10.1080/07391102.2022.2103028

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