Article
"Good enough solutions" and the genetics of complex diseases.
Circulation research - 3 Aug 2012
Weiss James N, Karma Alain, MacLellan W Robb, Deng Mario, Rau Christoph D, Rees Colin M, Wang Jessica, Wisniewski Nicholas, Eskin Eleazar, Horvath Steve, Qu Zhilin, Wang Yibin, Lusis Aldons J
Abstract excerpt
In this Emerging Science Review, we discuss a systems genetics strategy, which we call gene module association study (GMAS), as a novel approach complementing genome-wide association studies (GWAS), to understand complex diseases by focusing on how genes work together in groups rather than singly. The first step is to characterize phenotypic differences among a genetically diverse population. The second step is...
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