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Article

BiP prevents rod opsin aggregation.

Molecular biology of the cell - 1 Sept 2012

Athanasiou Dimitra, Kosmaoglou Maria, Kanuga Naheed, Novoselov Sergey S, Paton Adrienne W, Paton James C, Chapple J Paul, Cheetham Michael E

Abstract excerpt

Mutations in rod opsin-the light-sensitive protein of rod cells-cause retinitis pigmentosa. Many rod opsin mutations lead to protein misfolding, and therefore it is important to understand the role of molecular chaperones in rod opsin biogenesis. We show that BiP (HSPA5) prevents the aggregation of rod opsin. Cleavage of BiP with the subtilase cytotoxin SubAB results in endoplasmic reticulum (ER) retention and...

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Source

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Identifiers

PMID: 22855534
DOI: 10.1091/mbc.E12-02-0168
PMCID: PMC3442401

Genes

HSPA5

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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